17 Mohamed Arafa Tuncay Toprak Edmund Ko Rupin Shah Armand Zini Eric Chung Selahittin Cayan Germar-Michael Pinggera Widi Atmoko Tan Le Ayman Rashed Taras Shatylko Akira Tsujimura Hyun Jun Park Hussein Kandil Manaf Al Hashmi Marco Falcone Celeste Manfredi Haocheng Lin Andrian Japari Manh Nguyen Truong Mohammed Abdulgabbar Noman Jean de la Rosette Walter D. Cardona Maya Ashok Agarwal male infertility Web of Science Белый список 2025 2026-06-16 10.5534/wjmh.250269 THE WORLD JOURNAL OF MEN'S HEALTH The pathogenesis of male infertility is multifaceted, driven by a convergence of congenital, acquired, and idiopathic influences that collectively disrupt spermatogenesis [1]. Despite major progress in diagnostic tools and treatment options, many areas in the management of male infertility are still inconsistent and lacking clear guidelines. Key challenges include the absence of objective protocols for assessing idiopathic male infertility (IMI) [2], ongoing debates about the usefulness of sperm DNA fragmentation (SDF) testing [3], and the management of high SDF [4,5]. Important choices, such as medical treatment before surgical sperm retrieval (SSR) in men with non-obstructive azoospermia (NOA) [6], management of leukocytospermia [7], or SSR in men with cryptozoospermia, often rely on clinicians’ preference and experience instead of strong clinical evidence. These inconsistencies highlight the urgent need for standardization and evidence-based improvements in male infertility practice. This editorial aims to underscore areas in male infertility where clinical controversies persist and to call for consensusdriven, evidence-based guidance. https://repo.bashgmu.ru/publication/5524 https://repo.bashgmu.ru/files/5718