17 Blinov A. Rekhman Z. Gvozdenko A. Piskov S. Agzamov, V.V. Omelianov, N. Chagaev, Z. Morzaleva, D. Ismagilova, Iu. Gadaeva, D. Poladashvili M. Nagdalian A. nanomaterials nano medicine toxicity CAM assay Scopus Белый список 2025 2026-05-27 10.48309/jmpcr.2025.490259.1512 JOURNAL OF MEDICINAL AND PHARMACEUTICAL CHEMISTRY RESEARCH This work presents a study on the synthesis, characterization, and biocompatibility assessment of manganese carbonate nanoparticles (MC-NPs) stabilized with methylcellulose. Manganese acetate was used as a manganese-containing precursor, ammonium carbonate was used as a precipitator, and methylcellulose served as a stabilizing agent. The samples obtained exhibited a size distribution described as monomodal, though the relatively large standard deviation (±80 nm) suggests some variability, which should be noted. The average hydrodynamic radius was measured as 393 ± 80 nm. The phase composition of the samples was identified as manganese carbonate (MnCO3) with a rhombohedral crystal lattice belonging to the R-3c spatial group. MC-NPs samples were composed of spherical aggregates with diameters ranging from 0.4 to 2 µm. Quantum chemical modeling and IR spectroscopy revealed that the interaction between manganese carbonate and methylcellulose occurs through the OH– group attached to the C4 atom of the glucopyranose residue. While this interaction mechanism is briefly summarized, its specific relevance to the biocompatibility of the nanoparticles warrants further clarification. The biocompatibility of the obtained samples was evaluated using the chorioallantois membrane model of a chicken embryo and histological analysis. Results demonstrated that MC-NPs stabilized with methylcellulose are biocompatible, non-toxic, and hold great potential for multifaceted applications in medicine. https://repo.bashgmu.ru/publication/5437 https://repo.bashgmu.ru/files/5631