17 Samorodov, A.V. Yi, W. Kudlay, D.A. Smolyarchuk, E.A. Dobrynin, A.B. Khamatgalimov, A.R. Shchebneva, K. Kadomtseva, M. Komunarova, D. Strelnik, A.G. isatin phosphorus hydrazones crystal structure hemostasis antithrombotic activity Scopus Web of Science Белый список 2025 2026-05-21 10.3390/ijms26136147 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES A series of new isatin hydrazones bearing phosphorus-containing moiety was synthesized through a simple, high-yield and easy work-up reaction of phosphine oxide (Phosenazide) or phosphinate (2-chloroethyl (4-(dimethylamino)phenyl)(2-hydrazinyl-2- oxoethyl)phosphinate, CAPAH) hydrazides with aryl-substituted isatins. The 31P NMR technique showed that, in most cases, out of 12 examples in solution, the ratio of the two spatial isomers varied from 1:1 to 1:3. Quantum chemical calculations confirmed the predominance of Z,syn form both in the gas phase and in solution. According to X-ray analysis data in crystals, they exist only in Z,syn form too. Most of the phosphine oxide derivatives and 5-methoxy- and 5-bromoaryl phosphinate analogs exhibit anti-aggregant activity at the level of acetylsalicylic acid but inhibit platelet activation processes more effectively. The 5-chloro type phosphinate derivative exhibits anti-aggregant properties more effectively than acetylsalicylic acid under the conditions of the tissue factor (TF)-activated thromboelastography (TEG) model, the ex vivo thrombosis model. Thus, all the obtained results can become the basis for future pharmaceutical developments to create effective anti-aggregation drugs with broad antithrombotic potential. https://repo.bashgmu.ru/publication/5381 https://repo.bashgmu.ru/files/5574