PT - JOURNAL ARTICLE
AU - Valentin V. Kataev, 
AU - Valentina N. Perfilova, 
AU - Igor I. Prokofiev, 
AU - Alla A. Nesterova, 
AU - Yulia K. Isaeva, 
AU - Margarita V. Kustova, 
AU - Ivan N. Turenkov, 
AU - Anatoly K. Brel, 
AU - Kataev, V.A., 
TI - Cardioprotective effect of hydroxybenzoic acid ester containing neuroactive acid, compound F-26, in conditions of isoproterenol heart failure in rats
DP - 2026-05-18
TA - RESEARCH RESULTS IN PHARMACOLOGY
4100 - DOI 10.18413/rrpharmacology.11.811
SO - https://repo.bashgmu.ru/publication/5346
AB - Introduction: Chronic heart failure (CHF) is a leading public health problem. Its most common
manifestation is decreased cardiac inotropic reserve. Mitochondrial dysfunction and oxidative stress
contribute to the progression of CHF. Hydroxybenzoic acid derivatives limit mitochondrial
dysfunction and oxidative stress, thereby reducing their damaging effects on the heart.
Materials and Methods: Chronic heart failure (CHF) was modeled by intraperitoneal
administration of L-isoproterenol to male Wistar rats at a dose of 2.5 mg twice daily for 21 days.
Four groups of 14 animals each were formed: intact animals, a control group with CHF that
received saline solution, and experimental animals with CHF that received compound F-26 at a
dose of 7.9 mg/kg and mildronate –50 mg/kg intraperitoneally once daily throughout the CHF
simulation period. Cardiac inotropic function was assessed using functional tests: volume
loading, adrenergic receptor activation, and occlusion of the ascending aorta. Mitochondrial
oxygen uptake was determined using polarography. Myocardial morphometric analysis was
performed using micrographs.
Results and Discussion: Compound F-26 has a positive effect on cardiac inotropic reserves, as
evidenced by increases in myocardial contraction and relaxation rates, left ventricular pressure,
and maximum structural activity intensity (MSI) during functional tests. Compound F-26
improves mitochondrial respiration, reduces MDA concentration, increases SOD activity, and
has a positive effect on the cross-sectional area, thickness, and volume fraction of
cardiomyocytes and interstitium.
Conclusion: Compound F-26 improves cardiac inotropic function, mitochondrial function, the
antioxidant system of cardiomyocytes, and morphometric parameters.