RT - Article
SR - Electronic
T1 - Short-term effects of remote ischemic conditioning on vascular function in patients with cardiovascular diseases: a systematic review with meta-analysis
JF - EINSTEIN
SP - 2026-05-10
DO - 10.31744/einstein_journal/2025RW1937
A1 - Samuel Amorim, 
A1 - Gilberto Laurentino, 
A1 - Victor Sabino de Queiros, 
A1 - Yujia Liu, 
A1 - Per Aagaard, 
A1 - Charlotte Suetta, 
A1 - Zagidullin, N.Sh., 
A1 - Kenneth J. Gollob, 
YR - 2025
UL - https://repo.bashgmu.ru/publication/5285
AB - Objective: The purpose of this systematic review with meta-analysis was to compare the
short-term (≤1 month) effects of remote ischemic conditioning versus sham remote ischemic
conditioning on vascular function in patients with cardiovascular diseases. Methods: A systematic
review was conducted to identify relevant studies through six healthcare science databases up
to March 2025. Arterial stiffness and endothelial function were defined as the primary outcome.
Meta-analyses were performed using a random-effect model. Also, GRADE Pro software was
used to evaluate the quality of evidence. Results: A total of 7 randomized clinical trials with 603
patients with cardiovascular diseases were included in the systematic review. Also, we included
5 studies in the meta-analysis. Compared with sham remote ischemic conditioning or control,
short-term remote ischemic conditioning resulted in enhanced endothelial function (MD=4.22%
[95%CI=1.75; 6.69]; p=0.0008; I2
=0%) without any changes in arterial stiffness,
(MD=-0.05 m/s [95%CI =-0.77, 0.67]; p=0.89; I2
=89%). Conclusion: This systematic review
and meta-analysis found that short-term remote ischemic conditioning was associated with
improvements in endothelial function compared with sham remote ischemic conditioning or
control in cardiovascular patients, without any impact on arterial stiffness.