%0 Article
%A Samuel Amorim, 
%A Gilberto Laurentino, 
%A Victor Sabino de Queiros, 
%A Yujia Liu, 
%A Per Aagaard, 
%A Charlotte Suetta, 
%A Zagidullin, N.Sh., 
%A Kenneth J. Gollob, 
%T Short-term effects of remote ischemic conditioning on vascular function in patients with cardiovascular diseases: a systematic review with meta-analysis
%D 2025
%R 10.31744/einstein_journal/2025RW1937
%J EINSTEIN
%X Objective: The purpose of this systematic review with meta-analysis was to compare the
short-term (≤1 month) effects of remote ischemic conditioning versus sham remote ischemic
conditioning on vascular function in patients with cardiovascular diseases. Methods: A systematic
review was conducted to identify relevant studies through six healthcare science databases up
to March 2025. Arterial stiffness and endothelial function were defined as the primary outcome.
Meta-analyses were performed using a random-effect model. Also, GRADE Pro software was
used to evaluate the quality of evidence. Results: A total of 7 randomized clinical trials with 603
patients with cardiovascular diseases were included in the systematic review. Also, we included
5 studies in the meta-analysis. Compared with sham remote ischemic conditioning or control,
short-term remote ischemic conditioning resulted in enhanced endothelial function (MD=4.22%
[95%CI=1.75; 6.69]; p=0.0008; I2
=0%) without any changes in arterial stiffness,
(MD=-0.05 m/s [95%CI =-0.77, 0.67]; p=0.89; I2
=89%). Conclusion: This systematic review
and meta-analysis found that short-term remote ischemic conditioning was associated with
improvements in endothelial function compared with sham remote ischemic conditioning or
control in cardiovascular patients, without any impact on arterial stiffness.
%U https://repo.bashgmu.ru/publication/5285