17 Mustafin, R.N. circRNA colorectal cancer long noncoding RNA microRNA retroelements viral mimicry Scopus Белый список 2025 2026-05-02 10.24412/2500-2295-2025-2-89-113 OPERA MEDICA ET PHYSIOLOGICA Abstract. Colorectal cancer (CRC) is characterized by a high mutational load and resistance to chemotherapy. Therefore, new approaches in the treatment of CRC include viral mimicry aimed at activating the expression of retroelements to stimulate the immune response against cancer. However, the role of activated retroelements in CRC carcinogenesis must be considered. Retroelements are implicated in CRC-specific chromothripsis and one of the highest percentages of retroelement insertions in CRC of any cancer type has been identified. In addition, retroelements are evolutionarily and functionally related to long noncoding RNAs, microRNAs, and circular RNAs. Therefore, a differentiated approach is needed in targeted therapy of CRC using circular RNAs as tools (as the most stable non-coding RNAs) to control the activity of retroelements. This article describes the analysis of scientific literature on the relationship in the mechanisms of CRC development of retroelements with circular RNAs, microRNAs and long non-coding RNAs. Data on the func-tioning of specific circular RNAs as tumor suppressors and oncogenes with their influence on microRNA and the ex-pression of protein-coding genes are systematized. The nature of changes in the expression of transposon-derived microRNAs interacting with circRNAs and long noncoding RNAs in CRC is presented. The obtained data may form the basis for more correct epigenetic therapy of CRC with activation of only those retroelements that are not involved in CRC carcinogenesis. https://repo.bashgmu.ru/publication/5220 https://repo.bashgmu.ru/files/5413