Статья
ИССЛЕДОВАНИЕ ПРОТИВООПУХОЛЕВЫХ ЭФФЕКТОВ БЕРБЕРИНА НА КЛЕТКАХ ПЛОСКОКЛЕТОЧНОЙ КАРЦИНОМЫ ЯЗЫКА
2017
Squamous cell carcinoma of oral tongue belongs to highly invasive malignancies of head and neck area. The natural isoquinoline alkaloid berberine has demonstrated anti-tumor potential in various cancer types. This research was aimed to study in vitro effects of berberine in squamous cell carcinoma of oral tongue. Berberine reduced the proliferation of CAL-27 cells in a dosedependent manner (IC50 = 36μM). Furthermore, berberine strongly inhibited invasion of squamous cell carcinoma of oral tongue cells (EC50 = 0,9μM). Anti-proliferative and anti-invasive actions displayed by berberine in CAL-27 cell line suggest the in vitro anticancer efficacy of the natural isoquinoline alkaloid.
Тугузбаева, Г.М., Ю Эр, Павлов, В.Н., Юмэй Нью, Юнлонг Бай ИССЛЕДОВАНИЕ ПРОТИВООПУХОЛЕВЫХ ЭФФЕКТОВ
БЕРБЕРИНА НА КЛЕТКАХ ПЛОСКОКЛЕТОЧНОЙ
КАРЦИНОМЫ ЯЗЫКА. Медицинский вестник Башкортостана. 2017;:83-86.
Цитирование
