17 Епифанцева, Н.В. Витковский, Ю.А. острые кишечные инфекции полиморфизм ИЛ-10 диарея интоксикация 2022 2023-02-01 In the development, course and outcomes of acute intestinal infections, a significant role is played by the polymorphism of genes responsible for the induction of the synthesis of inflammatory molecules. Purpose of the work: to identify the features of the clinical picture depending on the polymorphism of the G1082A IL-10 gene and its effect on the induction of IL-10 synthesis. Material and methods. 108 people diagnosed with acute intestinal infection were studied. In the blood serum, the level of IL-10 was determined using the test systems of «Vector-Best», Novosibirsk. Determination of the polymorphism of the G1082A IL-10 gene was carried out by PCR using primers of «Litekh» LLC (St. Petersburg). Genomic DNA was analyzed. Statistical data pro-cessing was carried out using electronic programs Microsoft Excel 2010, Statistica 6.0. Results. In all the subjects, the predominance of the dominant allele G of the G1082A locus of the IL-10 gene was found. At the same time, in patients with acute intestinal infection, who are owners of the hypoproductive allele A in the -AA1082 variant of the IL-10 gene, a significant decrease in the expression of interleukin 10 was noted, which affected the course of the gastrointestinal tract lesion syndrome. Conclusions. The presence of the IL-10 G1082A gene polymorphism, without affecting the risk of developing acute intestinal infections, affects the induction of IL-10 expression and the clinical picture of the disease. https://repo.bashgmu.ru/publication/3987 https://repo.bashgmu.ru/files/4163