TY  - JOUR
T1  - 
DO  - 10.1134/S1070428022090020
AU  - , 
AU  - , 
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Y1  - 2022-11-18
UR  - https://repo.bashgmu.ru/publication/3688
N2  - Reactions of 2-(chloromethyl)thiirane with symmetrically substituted C-bromo/nitropyrazoles in water in the presence of bases were accompanied by thiirane–thietane rearrangement to afford 4-bromo(nitro)- and 3,5-dibromo-4-bromo(nitro)-1-(thietan-3-yl)-1H-pyrazoles as convenient intermediate products for further transformations. Possible modifications of the title compounds via oxidation to 1-(1-oxo-λ4-thietan-3-yl)- and 1-(1,1-dioxo-λ6-thietan-3-yl)pyrazoles, reactions with oxygen and nitrogen nucleophiles with the formation of thietane-containing 5-methoxy- and 5-(morpholin-4-yl)-1H-pyrazoles, and reduction to 4-amino-3-bromo-5-(morpholin-4-yl)-1-(thietan-3-yl)-1H-pyrazole have been demonstrated. © 2022, Pleiades Publishing, Ltd.