@article{2023-09-18,
author = {, , , ,  Авзалетдинова, Д.Ш.,  Кочетова, О.В.,  Булгакова, А.З.,  Моругова, Т.В.},
title = {Пищевое поведение и аллельные варианты гена рецептора лептина у пациентов с сахарным диабетом 2-го типа: одноцентровое поперечное исследование},
year = {2023},
doi = {10.47093/2218-7332.2023.14.1.15-26},
publisher = {NP «NEICON»},
abstract = {Aim. The aim of this study was to analyze eating behavior and leptin receptor (LEPR) gene in patients with type 2 diabetes mellitus (T2D). Materials and methods. 83 patients with T2D (62 women, 21 men) aged 59.0 ± 9.9 years and 134 people without clinical and laboratory signs of diabetes mellitus (105 women, 29 men) aged 55.0 ± 10.2 years were examined. Bulimia nervosa was excluded in all the patients. Eating behavior was assessed using Dutch Eating Behavior Questionnaire, V.A. Losenkov's Impulsivity Questionnaire. Genotyping of the LEPRgene rs1137100 marker was performed using polymerase chain reaction. The Mann-Whitney U-test and Pearson chi-square were used to compare the values of the variables; ROC-analysis was performed. Results. The emotional eating was more pronounced in T2D group (4.9 (4.1; 5.2) vs 3.1 (2.8; 3.8), p < 0.0001), but the restrained (2.8 (2.6; 3.6) vs 3.3 (2.6; 4.2), p < 0.0001) and external eating was less pronounced (3.3 (3.0; 3.8) vs 3.8 (3.3; 4.4), p < 0.0001), T2D patients were also less impulsive (47 (38; 66) vs 61 (54.5; 70), p < 0.0001). These differences for emotional eating are confirmed in both subgroup of excess body weight and in subgroups of all degrees of obesity. The best predictive model of T2D was obtained for emotional eating with a cut-off point 4.1 scores: sensitivity 74.7%, specificity 79.1%, AUROC = 0.777; 95% confidence interval: 0.715-0.830, p < 0.0001. The distribution of genotypes by the polymorphic marker rs1137100 of the LEPRgene was similar in both groups. Restrictive eating was lower in patients with GGgenotype compared to AA and GA(1.77 ± 0.52 vs 2.94 ± 0.08, p < 0.01). Conclusion. Patients with T2D are characterized by emotional eating behavior. The association of the polymorphic locus rs1137100 of the LEPRgene with restrained eating behavior in T2D suggests the presence of genetic factors for the formation of eating patterns. © 2023 Authors. All rights reserved.},
URL = {https://repo.bashgmu.ru/publication/3006},
eprint = {https://repo.bashgmu.ru/files/3182},
}