RT - Article
SR - Electronic
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SP - 2023-10-09
DO - 10.1007/s11172-023-3951-6
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YR - 2023
UL - https://repo.bashgmu.ru/publication/2998
AB - 2-Substituted 4,5-dihydro-1H-imidazoles were synthesized by the condensation of aromatic carboxylic acids with ethylenediamine in the presence of KU-2/8 cation-exchange resin as a catalyst. Subsequent alkylation of the resulting compounds with 2-chloromethyl-gem-dichlorocyclopropane or 2-bromomethyl-1,3-dioxolane gave previously unknown substituted imidazolines containing carbo- and heterocyclic fragments. The synthesized 2-substituted 4,5-dihydro-1H-imidazoles were found to possess the antiplatelet activity at the level of acetylsalicylic acid. © 2023, Springer Science+Business Media LLC.