PT - JOURNAL ARTICLE
AU - КОЧЕТОВА, О.В., 
AU - АХМАДИШИНА, Л.З., 
AU - АВЗАЛЕТДИНОВА, Д.Ш., 
AU - ШАНГАРЕЕВА, З.А., 
AU - КОРЫТИНА, Г.Ф., 
AU - , 
AU - , 
AU - , 
AU - , 
TI - МОЛЕКУЛЯРНЫЕ МАРКЕРЫ СД2 ПРИ ОЖИРЕНИИ: ЭКСПРЕССИОННЫЙ ПРОФИЛЬ ГЕНОВ, КЛЮЧЕВЫХ МОЛЕКУЛ ГЕНОВ ВОСПАЛИТЕЛЬНОГО ОТВЕТА В МОНОНУКЛЕАРНЫХ КЛЕТКАХ ПЕРИФЕРИЧЕСКОЙ КРОВИ
DP - 2022-03-29
4100 - 10.25557/2073-7998.2020.05.92-94
SO - https://repo.bashgmu.ru/publication/2496
AB - Type 2 diabetes mellitus (T2DM) is a metabolic multifactorial, genetically determined, life-threatening disease. The development of complications is associated with a chronic immuno-inflammatory process and with the formation of immune complexes. The aim of the study was to analyze the expression profile of a complex of functionally interconnected genes (cytokines, chemokines, and other key molecules of the inflammatory response) in peripheral blood mononuclear cells in patients with T2DM (N = 10) and in the control group (N = 10). Patients and controls were matched by gender, age, and belonged to the Tatars ethnic group. The expression profile of 84 immune response genes was studied by OT-PCR on a BioRad CFX96TM instrument using the Human Cytokines & Chemokines PCR Array RT2 Profiler PCR Arrays kit (Qiagen). Significant changes in expression (p