2021

2021-06-30

10.1007/s11094-021-02402-3 A new method for the synthesis of glycyrrhizic acid (GA) conjugates with S-benzyl-L-cysteine using 1-ethyl-3-(3-dimethylaminoproopyl)carbodiimide is proposed. It is established that 3-O-{2-O-[N-(beta-D-glucopyranosyluronyl)-L-cysteine-S-benzyl]-N-(beta-D-glucopyranosyluronyl)-L-cysteine-S-benzyl}-(3 beta,20 beta)-11-oxo-30-(N-carbonyl-L-cysteine-S-benzyl)-30-norolean-12-ene is superior to GA in inhibiting the accumulation of HIV-I virus-specific protein p24 (viral antigen) in MT-4 cell culture (IC50 3 mu g/mL, SI 90) and is 50 - 55 times less toxic to cells than azidothymidine.

https://repo.bashgmu.ru/publication/2029

https://repo.bashgmu.ru/files/2201