To study the features of clinical manifestations of helminthiasis in HIV-infection and characteristics of clinical and laboratory parameters in parasitic infestations in groups of HIV-infected patients with helminthiasis. There were 168 people in the study. Of these, two groups of HIV-infected – 109 people with helminthiasis and 29 people without helminthiasis, 30 people – a control group of healthy people without HIV infection with helminthiasis on the basis of the Republican center for prevention and control of AIDS and infectious diseases, Ufa, Russia for 2016–2017. Clinical and laboratory parameters were analyzed. In a study taken patients with HIV-infection in the subclinical stage 3 without ART, with an established method of moprovskaja helminthiasis. The clinical picture of helminthiasis in HIV-infected was more severe than in people without HIV infection. Gastrointestinal disorders were 4 times more common in HIV-infected people with helminthiasis. There was a high level of allergic reactions in the clinic of helminthiasis in patients with HIV pathology. Also in HIV-infected patients revealed changes of quantitative indicators of leucoformula, in particular, of eosinophils. In 93.1% of cases of helminthiasis in HIV-infected patients was observed expressed hypereosinophilia. The study showed a positive effect of deworming on eosinophils in HIV-infection.