TY  - JOUR
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DO  - 10.1134/S1070363221070045
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Y1  - 2021-09-16
UR  - https://repo.bashgmu.ru/publication/1660
N2  - Abstract: The click reaction of propargylisatins with some azido-sugars was used to synthesize new isatin derivatives, in which the carbohydrate residue is linked to the 2,3-dioxindole scaffold via the 1,2,3-triazole ring. A number of water-soluble acylhydrazones with various structure of cationic fragment were obtained on their basis. It was shown that the newly obtained compounds do not exhibit hemotoxic action and have a significant antiaggregatory and anticoagulant activity at the level of reference drugs such as acetylsalicylic acid and pentoxifylline. [Figure not available: see fulltext.]. © 2021, Pleiades Publishing, Ltd.