TY  - JOUR
T1  - РОЛЬ ПОЛИМОРФНЫХ ВАРИАНТОВ ГЕНА ОСТЕОПРОТЕГЕРИНА, РЕЦЕПТОРА ВИТАМИНА D И САЙТОВ СВЯЗЫВАНИЯ МИКРОРНК В РАЗВИТИИ ОСТЕОПОРОЗА
DO  - 10.15643/faaigi-2020-19
AU  - Ялаев, Б.И., 
AU  - Тюрин, А.В., 
AU  - Нурлыгаянов, Р.З., 
AU  - Хусаинова, Р.И., 
AU  - , 
AU  - , 
AU  - , 
AU  - , 
Y1  - 2021-01-28
UR  - https://repo.bashgmu.ru/publication/1259
N2  - Osteoporosis (OP) is one of the most common multifactorial diseases
among the elderly population, which is characterized by a high risk of fractures
and microarchitectural disorders of bone tissue. A comprehensive study of the
genetic and epigenetic factors of this disease and the specifics of their
contribution to the structure of OP pathogenesis is relevant [1-2]. The
development of OP depends on genetic factors that determine 80% of the
variability in the level of bone mineral density (BMD) and 25% of fractures [3].
We found an association of rs11540149, rs6854081, rs10098470, rs10793442,
rs1054204 of microRNA binding sites, rs3134069, rs3102734 and rs7844539 of
the OPG gene and rs1544410 of the VDR gene with the risk of fractures and the
formation of low BMD. These data indicate differences in the pathogenesis of
OP related to sexual differences in the regulation of bone metabolism and the
different contribution of these loci to the risk of osteoporosis developing