17 Ялаев, Б.И. Тюрин, А.В. Нурлыгаянов, Р.З. Хусаинова, Р.И. 2020 2021-01-28 10.15643/faaigi-2020-19 Osteoporosis (OP) is one of the most common multifactorial diseases among the elderly population, which is characterized by a high risk of fractures and microarchitectural disorders of bone tissue. A comprehensive study of the genetic and epigenetic factors of this disease and the specifics of their contribution to the structure of OP pathogenesis is relevant [1-2]. The development of OP depends on genetic factors that determine 80% of the variability in the level of bone mineral density (BMD) and 25% of fractures [3]. We found an association of rs11540149, rs6854081, rs10098470, rs10793442, rs1054204 of microRNA binding sites, rs3134069, rs3102734 and rs7844539 of the OPG gene and rs1544410 of the VDR gene with the risk of fractures and the formation of low BMD. These data indicate differences in the pathogenesis of OP related to sexual differences in the regulation of bone metabolism and the different contribution of these loci to the risk of osteoporosis developing https://repo.bashgmu.ru/publication/1259 https://repo.bashgmu.ru/files/1429