%0 Article
%A , 
%A , 
%A БЕЙЛЕРЛИ, О.А., 
%A ГАРЕЕВ, И.Ф., 
%T Длинные некодирующие РНК: какие перспективы?
%D 2020
%R 10.17116/profmed202023021124
%X Large-scale genomic analysis has demonstrated the existence of many long non-coding RNAs (lncRNAs). Although the function of most of these lncRNAs is currently unexplored, it is clear that many of these transcripts play an important role in regulating gene expression and are involved in various pathologic conditions, including cancer. The perception of lncRNAs as fragments of RNA and transcriptional noise has been constantly replaced by their role as confirmed targets for a variety of physiological processes over the past few years. Functional studies have shown the involvement of lncRNAs in various physiological processes. Their role at all stages of carcinogenesis and in modulating metastasis through regulatory networks was found. Aberrant expression of lncRNAs in cancer patients has been observed. In this context, lncRNAs can regulate the basic characteristics of cancer cells by controlling gene expression programs associated with their suppressive and oncogenic functions. Therefore, they can be excellent biomarkers and therapeutic targets for cancer. This review summarizes current knowledge about the biology of lncRNAs and their functions in normal and pathological conditions.
%U https://repo.bashgmu.ru/publication/1061