@article{2020-11-23,
author = {, , },
title = {},
year = {2020},
doi = {10.1007/s10600-020-03095-y},
publisher = {NP «NEICON»},
abstract = {Glycyrrhizic acid (GA, 1) is the main triterpene glycoside from roots of Glycyrrhiza glabra L. and G. uralensis Fisch. and a leading natural glycoside with potential as a medicine for developing new immunomodulators and antiviral agents [1, 2]. Several conjugates of GA with amino acids and dipeptides displayed pronounced antiviral activity against human immunodeficiency (HIV) [3, 4], atypical pneumonia of SARS-CoV [5], Epstein–Barr [6], and flu A/H1N1 viruses [7]. Previously, we proposed methods for preparing conjugates of GA with alkyl and benzyl esters of L- and D-amino acids via activation of the GA carboxylic acids using N-hydroxybenzotriazole (HOBt) and N,N′-dicyclohexylcarbodiimide (DCC) [8], N-hydroxyphthalimide and DCC [9], or N-hydroxysuccinimide (HOSu) and DCC [3]. The main drawback of these methods for preparing amino-acid conjugates of GA is their two steps (preparation of GA activated ester and subsequent reaction of it with an amine). Furthermore, the dicyclohexylurea formed if DCC is used contaminates the target conjugates. Therefore, water-soluble carbodiimides, in particular 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (DEC), which does not form dicyclohexylurea, are more attractive as condensing reagents.},
URL = {https://repo.bashgmu.ru/publication/1059},
eprint = {https://repo.bashgmu.ru/files/1212},
}