Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate

Bogdanov, A.V.; Ivanova, A.A.; Voloshina, A.D.; Rakhmatullin, R.R.; Samorodov, A.V.; Valiullina, Z.A.; Krylova, I.D.; Bukharov, S.V.

Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate

Bogdanov, A.V., Ivanova, A.A., Voloshina, A.D., Rakhmatullin, R.R., Samorodov, A.V., Valiullina, Z.A., Krylova, I.D., Bukharov, S.V.

Publication date: 2024

DOI: 10.1134/S1070363224080085

Abstract:

New phosphorus-containing isatin-3-hydrazones were synthesized by the condensation reaction of 5-substituted isatins with 2-chloroethyl [4-(dimethylamino)phenyl](2-hydrazinyl-2-oxoethyl)phosphinate (KAPAKh). The resulting compounds were shown to have high antitumor activity against duodenal adenocarcinoma (HuTu80) and cervical epithelioid carcinoma (M-HeLa) cell lines with low toxicity towards erythrocytes and normal human liver cells. © Pleiades Publishing, Ltd. 2024.

Keywords:
biological activity, hydrazones, isatin, phosphine oxides, phosphorus, Scopus

Издатель: Pleiades Publishing

Тип: Article

Synthesis and Antitumor Activity of Hybrid Compounds Based on Aryl-Substituted Isatins and 2-Chloroethynyl (4-(Dimetylamino)phenyl)(2-hydrazinyl-2-oxoethyl)phosphinate

Фасеты

Оппонент

Научный руководитель

Авторы

Ключевые слова

Год