Publication date: 2024

DOI: 10.1007/s11094-024-03070-9

The main goal of applying antiplatelet drugs is a reduced probability of thrombosis so that active substances that are superior to reference drugs in terms of the level and spectrum of their antiplatelet activity are being sought. Several amides of abietic and maleopimaric acids were synthesized and their anticoagulation and antiplatelet activity studied using the Born method and clotting tests. The synthesized amides of the diterpenic acids had different effects on the plasma component of the hemostasis system, which manifested as a change in the internal blood coagulation pathway, i.e., the activated partial thromboplastin time, without affecting the fibrinogen concentration and prothrombin time. The N-phenylamide and N-(p-fluoro)phenylamide of abietic and maleopimaric acids and the N-morpholylamide of maleopimaric acid exhibited antiplatelet activity comparable to the widely used antiplatelet agent and cyclooxygenase-1 inhibitor acetylsalicylic acid and more effectively inhibited the platelet release reaction (lag period in collagen-induced platelet aggregation). © Springer Science+Business Media, LLC, part of Springer Nature 2024.

Издатель: Springer

Тип: Article