Дата публикации: 2018

The objects were 45 patients with a furuncle of the maxillofacial region (FMFR). The polymorphism of genes determining the pathogenicity and antibiotic resistance of S. aureus pure culture, isolated of FMFR, has been studied. The following immunological features of patients with FMFR has been shown: lymphopenia, decreased level of total T-lymphocytes (CD3+), suppression of neutrophils phagocytic activity, selective IgA deficiency and an increase concentration of IgG in the group of patients with relapsing course. The discharge of the wound in 58.54 % of cases detected methicillin-resistant strains of S. aureus (MRSA). Clinical strains of S. aureus were distinguished by the presence of fragments of genes cytolytic toxin (PVL-F) and staphylococcal enterotoxin c (SEC3), in 58.54 % and 41.46 % cases, respectively, which was accompanied by frequent relapses of the disease. Thus, an active mobilization of protective factors in the dysbiotic process of the skin microecosystem with suppression of some natural defense mechanisms was observed. The presence of two leading genetic markers of S. aureus, expressing toxin PantonValentine leucocidin (PVL-F) and enterotoxin C3 (SEC3) can determine the development and recurrence of FMFR, and confirms the etiologically significant role of S. aureus present on the mucosa of the nasal passages, throat and skin. © 2018 Stavropol State Medical University. All rights reserved.

Издатель: Stavropol State Medical University

Тип: Article

DOI: 10.14300/mnnc.2018.13011