Oxo- and dioxothietane derivatives of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4-(1H,3H)-dione were synthesized
by oxidation. N-Alkylation and CH-aminomethylation produced 3-alkyl- and 5-aminomethyl-substituted
and 1-(1,1-dioxothietan-3-yl)-6-methylpyrimidine-2,4-(1H,3H)-dione. The synthesized
compounds showed hypotensive activity. Compounds causing pronounced, prolonged, and dose-dependent
hypotensive effects that were comparable with those of reference drugs nebivolol (2 mg/kg), lisinopril
(10 mg/kg), and amlodipine (1 mg/kg) were discovered.