Publication date: 2017

DOI: 10.1002/slct.201601988

A new Ti-catalyzed cross-cyclomagnesiation of aliphatic and oxygenated 1,2-dienes with EtMgBr in the presence of Cp2TiCl2 was used in the key stage for the development for the first time original methods for the preparation of racemic and natural neuritogenic alkynes lembehyne B and stereoselective syntheses of (4Z,8Z)-pentacosa-4,8-dien-1-ol - the key intermediate in the total synthesis of lembehyne A.

Тип: Article