Synthesis and Antimicrobial, Antiplatelet, and Anticoagulant Activities of New Isatin Deivatives Containing a Hetero-Fused Imidazole Fragment

Bogdanov, AV; Sirazieva, AR; Voloshina, AD; Abzalilov, TA; Mironov, VF

Synthesis and Antimicrobial, Antiplatelet, and Anticoagulant Activities of New Isatin Deivatives Containing a Hetero-Fused Imidazole Fragment

Bogdanov, AV, Sirazieva, AR, Voloshina, AD, Abzalilov, TA, Abzalilov, TA, Mironov, VF

Publication date: 2022

DOI: 10.1134/S1070428022030101

Abstract:

A series of isatin derivatives containing an adenine or theophylline fragment have been synthesized. The corresponding N '-[2-(trimethylammonio)acetyl] and N '-(2-pyridinioacetyl) hydrazones have been found to exhibit neither cytotoxicity nor hemotoxicity. Quaternary salts based on adenine derivatives of 5-methyl- and 5-ethylisatins showed the highest antiplatelet activity which exceeded the activity of acetylsalicylic acid by a factor of 1.5.

Keywords:
isatin, xanthines, hydrazones, antimicrobial activity, hemotoxicity, anticoagulants, antiplatelet activity, Web of Science, Scopus

Издатель: MAIK NAUKA/INTERPERIODICA/SPRINGER233 SPRING ST, NEW YORK, NY 10013-1578

Тип: Article

Synthesis and Antimicrobial, Antiplatelet, and Anticoagulant Activities of New Isatin Deivatives Containing a Hetero-Fused Imidazole Fragment

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