Synthesis and diverse biological activity profile of triethyl-ammonium isatin-3-hydrazones

Bogdanov, A; Tsivileva, O; Voloshina, A; Lyubina, A; Amerhanova, S; Burtceva, E; Bukharov, S; Samorodov, A; Pavlov, V

Synthesis and diverse biological activity profile of triethyl-ammonium isatin-3-hydrazones

Bogdanov, A, Tsivileva, O, Voloshina, A, Lyubina, A, Amerhanova, S, Burtceva, E, Bukharov, S, Samorodov, A, Pavlov, V

Publication date: 2022

Abstract:

A series of biorelevant triethylammonium isatin hydrazones containing various substituents in the aromatic fragment have been synthesized. Their structure and composition were confirmed by NMR-and IR-spectroscopies, mass-spectrometry and elemental analysis. It was found that some representatives show activity against Staphylococcus aureus and Bacillus cereus higher or at the level of norfloxacin, including methicillin-resistant Staphylococcus aureus strains. The study also showed low hemo-and cytotoxicity (Chang Liver) and high antiaggregatory and anticoagulant activity of these compounds. The high potential of new ammonium isatin-3-acylhydrazones in the search for antimicrobial activity against phytopathogens of bacterial and fungal nature has been shown for the first time. (C) 2021 by the authors.

Keywords:
isatin, hemostasis, phytopathogens, antibacterial and antifungal activities, Web of Science

Издатель: IAPC PUBLISHINGS ALICA 4, ZAGREB HR-10000, CROATIA

Тип: Article

Synthesis and diverse biological activity profile of triethyl-ammonium isatin-3-hydrazones

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