Publication date: 2015

Heterocyclic carboxylic acid hydrazides are promising building blocks in fine organic synthesis. We previously studied reactions of 2-[6-methyl-2,4-dioxo1-(thietan-3-yl)-1,2,3,4-tetrahydropyrimidin-3-yl]- acetohydrazide (1) with β-dicarbonyl compounds [1] and its condensations with aromatic aldehydes and ketones [2]. Some newly synthesized derivatives of hydrazide 1 were found to exhibit hypotensive [2] and antioxidant activity [3]. In continuation of studies of the reactivity of acetohydrazides containing thietanyl-, 1-oxothietanyl-, and 1,1-dioxothietanylpyrimidine fragments, the present communication reports on their reaction with N-phenylmaleimide.

Тип: Article

DOI: 10.1134/S1070428015010285