THIETANYL PROTECTION IN THE SYNTHESIS OF 1-ALKYL-8-AMINO-3-METHYL-3,7-DIHYDRO-1H-PURINE-2,6-DIONES

Publication date: 2015

Abstract:

1-Alkyl-8-bromo-3-methyl-7-(1,1-dioxo-1λ6-thietan-3-yl)-3,7-dihydro-1H-purine-2,6-diones reacted with amines to give the corresponding 1-alkyl-8-amino-3-methyl-7-(1,1-dioxo-1λ6-thietan-3-yl)-3,7-dihydro-1H-purine-2,6-diones which were treated with sodium alkoxide to remove thietanyl protecting group with formation of 1-alkyl-8-amino-3-methyl-3,7-dihydro-1H-purine-2,6-diones possessing no substituent on N7.

Тип: Article

DOI: 10.1134/S1070428015100139