SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF THIETANYLPYRIMIDIN-2,4(1H,3H)-DIONE ACETANILIDES AND ACETYLHYDRAZONES

Abstract:

Alkylation of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1H,3H)-dione with chloroacetanilides yielded N-acetanilide derivatives. Interaction of 2-(4-methyl-2,6-dioxo-3-thietan-3-yl-3,6-dihydropyrimidin-1(2H)acetohydrazide with carbonyl compounds was used to synthesize arylaldehyde and ketone N-acetylhydrazones. The antimicrobial and antifungal activities of the compounds synthesized here were studied.

Тип: Article