SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF THIETANYLPYRIMIDIN-2,4(1H,3H)-DIONE ACETANILIDES AND ACETYLHYDRAZONES

Meshcheryakova, S.A.; Kataev, V.A.; Fattakhova, I.Ya.; Nikolaeva, K.V.; Bulgakov, A.K.

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF THIETANYLPYRIMIDIN-2,4(1H,3H)-DIONE ACETANILIDES AND ACETYLHYDRAZONES

Publication date: 2015

Abstract:

Alkylation of 6-methyl-1-(thietan-3-yl)pyrimidine-2,4(1H,3H)-dione with chloroacetanilides yielded N-acetanilide derivatives. Interaction of 2-(4-methyl-2,6-dioxo-3-thietan-3-yl-3,6-dihydropyrimidin-1(2H)acetohydrazide with carbonyl compounds was used to synthesize arylaldehyde and ketone N-acetylhydrazones. The antimicrobial and antifungal activities of the compounds synthesized here were studied.

Keywords:
thietane, pyrimidin-2,4-(1H,3H)-dione, N-acetanilides, N-acetylhydrazones, antimicrobial, antifungal activity

Тип: Article

DOI 10.1007/s11094-015-1336-3

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF THIETANYLPYRIMIDIN-2,4(1H,3H)-DIONE ACETANILIDES AND ACETYLHYDRAZONES

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