Publication date: 2021

DOI: 10.1134/S2079057021040081

The paper summarizes data on the existence of evolutionarily fixed species balance of interactions between peptides, RNA, and DNA that provide the stability of the development and functioning of tissues and organs in ontogenesis. Identification of key structures that disturb this balance with aging can become a basis for a specific targeted effect on reversible epigenetic mechanisms of their origin. Non-coding RNAs that, in addition to the function of ribozymes and effectors of RNA interference, are capable of being translated into peptides, which can be the most convenient targets. The effect of the latter on non-coding RNAs and involvement in the same biological processes can become a basis for a complex approach in the development of new geroprotective drugs. It was suggested that peculiarities of the expression of non-coding RNAs typical for a cell type and stage of development reflect transposon activation patterns (programmed at the species level) required for setting of tissue-specific gene networks. This is caused by the formation of non-coding RNAs from transposon transcripts that are regulators of the expression of protein-coding genes in successive cell divisions.

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Тип: Article