Synthesis and Antiaggregant and Anticoagulant Activity of New 1-(4-Alkyloxybenzyl)-1H-Azoles and 1-(Adamantyl-1)-2-[4-(1H-Azol-1-Ylmethyl)-Phenoxy]Ethanones

Gurevich, KG; Urakov, AL; Basantsev, AV; Abzalilov, TA; Bashirov, II; Danilin, AA; Purygin, PP; Golovanov, AA; Khayrzamanova, KA; Samorodov, AV

Synthesis and Antiaggregant and Anticoagulant Activity of New 1-(4-Alkyloxybenzyl)-1H-Azoles and 1-(Adamantyl-1)-2-[4-(1H-Azol-1-Ylmethyl)-Phenoxy]Ethanones

Gurevich, KG, Urakov, AL, Basantsev, AV, Abzalilov, TA, Bashirov, II, Danilin, AA, Purygin, PP, Golovanov, AA, Khayrzamanova, KA, Samorodov, AV

Publication date: 2021

DOI: 10.1007/s11094-021-02491-0

Abstract:

The development and optimization of synthetic methods for alkyl esters of 4-[(1H-azol-1-yl)methyl]phenols enabled the expansion of organic synthesis methodology, which is extremely important for designing new structures with various types of biological activity, e.g., antiaggregant and anticoagulant. The present work studied O-alkylation of 4-[(1H-azol-1-yl)methyl]phenols with various alkylating agents, e.g., n-octyl bromide, n-hexadecyl bromide, and (adamantyl-1)bromomethylketone. The newly synthesized compounds were identified using elemental analysis and IR and PMR spectroscopy. Laboratory studies of blood isolated from healthy volunteers revealed compounds with antiaggregant and anticoagulant properties.

Keywords:
4-[(1H-azol-1-yl)methyl]phenols, n-octyl bromide, n-hexadecyl bromide, (adamantyl-1)bromomethylketone, antiaggregant activity, anticoagulant activity, Web of Science, Scopus

Издатель: SPRINGERONE NEW YORK PLAZA, SUITE 4600 , NEW YORK, NY 10004, UNITED STATES

Тип: Article

Synthesis and Antiaggregant and Anticoagulant Activity of New 1-(4-Alkyloxybenzyl)-1H-Azoles and 1-(Adamantyl-1)-2-[4-(1H-Azol-1-Ylmethyl)-Phenoxy]Ethanones

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