Publication date: 2014

DOI: 10.1007/s11094-014-1102-y

The structural characteristics typical of highly and moderately effective antagonists of BLT1 and BLT2 receptors were identified and the extents of their influences on the target property were evaluated. Two models for predicting inhibitory activity were constructed for series of sulfur-, nitrogen- and oxygen-containing heterocyclic compounds with significant prognostic levels of greater than 80% using two methods based on sample recognition theory. These structural patterns can be used for virtual screening of potential drugs for antiallergic activity associated with blockade of leukotriene LTB4-sensitive BLT1 and BLT2 receptors. © 2014, Springer Science+Business Media New York.

Издатель: Springer New York LLC

Тип: Article