Synthesis of Glycyrrhizic Acid Conjugates with S-Benzyl-L-Cysteine and Their Antiviral Activity

Baltina, L.A .; Kondratenko, M; Baltina, A; Plyasunova, O.A.

Synthesis of Glycyrrhizic Acid Conjugates with S-Benzyl-L-Cysteine and Their Antiviral Activity

Baltina, L.A ., Kondratenko, M, Baltina, A, Plyasunova, O.A.

Publication date: 2021

Abstract:

A new method for the synthesis of glycyrrhizic acid (GA) conjugates with S-benzyl-L-cysteine using 1-ethyl-3-(3-dimethylaminoproopyl)carbodiimide is proposed. It is established that 3-O-{2-O-[N-(beta-D-glucopyranosyluronyl)-L-cysteine-S-benzyl]-N-(beta-D-glucopyranosyluronyl)-L-cysteine-S-benzyl}-(3 beta,20 beta)-11-oxo-30-(N-carbonyl-L-cysteine-S-benzyl)-30-norolean-12-ene is superior to GA in inhibiting the accumulation of HIV-I virus-specific protein p24 (viral antigen) in MT-4 cell culture (IC50 3 mu g/mL, SI 90) and is 50 - 55 times less toxic to cells than azidothymidine.

Keywords:
glycyrrhizic acid, S-benzyl-L-cysteine, conjugates, synthesis, anti-HIV activity, Web of Science, Scopus, Web of Science

Издатель: SPRINGER, ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES

Тип: Article

Synthesis of Glycyrrhizic Acid Conjugates with S-Benzyl-L-Cysteine and Their Antiviral Activity

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