Publication date: 2021

DOI: 10.1134/S1022795421050045

Obesity and related complications are caused by eating disorders. The complex pathogenesis of the formation of food dependence has a genetic basis. This paper investigates the relationship between polymorphic variants of genes coding for glutamate receptors (GRIK5 rs8099939, GRIK3 rs534131, GRIA1 rs2195450, GRIN2B rs7301328, rs2268132, rs1805476, GRIN1 rs6293), (GABA) B receptor (GABBR2 rs3750344), serotonin receptor (HTR2A rs6313, rs6311), brain-derived neurotrophic factor (BDNF rs925946, rs11030107), and transmembrane protein 18 (TMEM18 rs2860323, rs6548238) with eating disorders in overweight and obese patients. BMI is shown to be associated with genotype GG of locus rs6293 of gene GRIN1, CC-AC of GRIK5 rs8099939, CC-CT of TMEM18 rs6548238, and CT-TT of GRIA1 rs2195450. Disorder of restrained eating behavior was identified in AC-AA genotype carriers at locus rs1805476 of gene GRIN2B (P = 0.04) and GG genotype carriers at locus rs6293 of gene GRIN1 (P = 0.028). Upset of emotional eating was characteristic of A allele carriers at locus rs1805476 of gene GRIN2B (P = 0.005) and AC-CC genotype carriers. Extern eating disorder was observed for carriers of genotypes AA and AC at the polymorphic locus rs1805476 of gene GRIN2B (P = 0.0003). Thus, polymorphisms of the glutamate and serotonin receptor genes, as well as the transmembrane protein 18 gene, are important factors in the development of eating disorders and obesity.

Издатель: PLEIADES PUBLISHING INC, PLEIADES HOUSE, 7 W 54 ST, NEW YORK, NY, UNITED STATES

Тип: Article