АНАЛИЗ АССОЦИАЦИЙ ПОЛИМОРФНЫХ ВАРИАНТОВ ГЕНОВ АМИНОКСИДАЗЫ 1 AOC1 И ГИСТАМИН-N-МЕТИЛТРАНСФЕРАЗЫ HNMT С РАЗВИТИЕМ БРОНХИАЛЬНОЙ АСТМЫ У ДЕТЕЙ

Дата публикации: 2020

DOI: 10.25789/YMJ.2020.72.05

Аннотация:

The significance of polymorphic variants of amino oxidase AOC1 and histamine-N-methyltransferase HNMT genes, involved in histamine metabolism, with predicting the risk of developing bronchial asthma (BA) in children living in the Republic of Bashkortostan was evaluated. Associations of the rs1049793 * CC genotype and the rs1049793 * C allele of the AOC1 gene with the development of.. were revealed with significant reductions in spirography indices in children of Russian ethnicity. There were associations of the rs1801105 * CT genotype and the rs1801105 * T allele of the HNMT gene with a significant decrease in MEF25 in BA patients of Tatar ethnicity. The results of this study indicate the role of polymorphic variants of the AOC1 and HNMT genes in the development of BA.

Издатель: RUSSIAN ACAD SCIENCES SIBERIAN BRANCH, S P C U I G G M S B R A S, 3 AKADEMIKA KOPTYGA PROSPEKT, 630090 NOVOSIBIRSK, RUSSIA

Тип: Article



Association analysis of amine oxidase 1 AOC1 and histamine-N-methyl-transferase HNMT genes polymorphism with the development of asthma in children

Publication date: 2020

DOI: 10.25789/YMJ.2020.72.05

Издатель: RUSSIAN ACAD SCIENCES SIBERIAN BRANCH, S P C U I G G M S B R A S, 3 AKADEMIKA KOPTYGA PROSPEKT, 630090 NOVOSIBIRSK, RUSSIA

Тип: Article