Publication date: 2019

DOI: 10.1016/j.psyneuen.2018.12.116

Background:Although alterations of the limbic hypothalamicpituitary adrenal (LHPA) axis are well documented in Chernobylclean-up workers, little is known concerning their implications todevelop a post-traumatic stress disorder (PTSD). Dysfunctional freeradical oxidation and their impact on PTSD remain unclear. Here weperformed a pilot study focused on the impact of cortisol treatmenton the lipid peroxidation levels in erythrocytes of PTSD relatedsubjects.Methods:The study was conducted among 86 Chernobyl clean-up workers. The washed Red Blood Cells in isotonic solutionpreparations were incubated with cortisol (37◦C) to a final con-centration of 10−5,10−6,10−7M. Red Blood Cells (RBCs) contentof lipid peroxidation (UE) products were studied by an extractionspectrophotometric method.Results:Post hoc analysis revealed decreased propanol 2-soluble diene conjugate levels in PTSD-related subjects with andwithout nuclear contact compared with the healthy control group.Exogenous cortisol treatment increases propanol 2-soluble Ketodi-ens and conjugated triene levels in our mental burdened groups.Conclusion:Our data with cortisol-treated RBC showed thecapacity of glucocorticoids for the upregulation of lipid peroxida-tion indicating a possible strategy to deal with trauma and stressorrelated disorders.

Издатель: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND

Тип: Article