Synthesis and Anti-Aggregation Activity of 2-[3-Methyl-1-Ethylxanth-8-Ylthio]Acetate Salts Containing Thietanyl and Dioxothietanyl Rings

Gurevich, K.G.; Urakov, A.L.; Khaliullin, F.A.; Samorodov, A.V.; Shabalina, Y.V.; Kamilov, F.K.; Murataev, D.Z.; Bashirova, L.I.

Synthesis and Anti-Aggregation Activity of 2-[3-Methyl-1-Ethylxanth-8-Ylthio]Acetate Salts Containing Thietanyl and Dioxothietanyl Rings

Gurevich, K.G., Urakov, A.L., Khaliullin, F.A., Samorodov, A.V., Shabalina, Y.V., Kamilov, F.K., Murataev, D.Z., Bashirova, L.I.

Publication date: 2020

DOI: 10.1007/s11094-020-02220-z

Abstract:

Reactions of 2-[1-ethyl-3-methyl-7-(thietan-3-yl)- and 2-[1-ethyl-3-methyl-7-(1,1-dioxothietan-3-yl)xanth- 8-ylthio]acetic acids with amines (diethylamine, monoethanolamine, diethanolamine, triethanolamine, piperidine, cyclohexylamine, and benzylamine) gave 42 – 89% yields of 2-[1-ethyl-3-methyl-xanth-8-ylthio]- acetate salts containing thietanyl and dioxothietanyl rings. The structures of the synthesized compounds were confirmed using IR and PMR spectroscopy. The synthesized compounds exhibited anti-aggregation activity. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

Keywords:
anti-aggregation activity, thietanes, xanthines, Scopus, Web of Science

Издатель: Springer

Тип: Article

Synthesis and Anti-Aggregation Activity of 2-[3-Methyl-1-Ethylxanth-8-Ylthio]Acetate Salts Containing Thietanyl and Dioxothietanyl Rings

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