DNA DAMAGE REPAIR ALTERATIONS MODULATE M2 POLARIZATION OF MICROGLIA TO REMODEL THE TUMOR MICROENVIRONMENT VIA THE P53-MEDIATED MDK EXPRESSION IN GLIOMA

MENG, X.; DUAN, C.; PANG, H.; CHEN, Q.; HAN, B.; MAGAFUROV, D.A.; WU, P.; LI, Z.; ZHAO, S.; WANG, R.; LIN, L.; JIANG, C.; CAI, J.; ZHA, C.

DNA DAMAGE REPAIR ALTERATIONS MODULATE M2 POLARIZATION OF MICROGLIA TO REMODEL THE TUMOR MICROENVIRONMENT VIA THE P53-MEDIATED MDK EXPRESSION IN GLIOMA

MENG, X., DUAN, C., PANG, H., CHEN, Q., HAN, B., MAGAFUROV, D.A., WU, P., LI, Z., ZHAO, S., WANG, R., LIN, L., JIANG, C., CAI, J., ZHA, C.

Publication date: 2019

DOI: 10.1016/j.ebiom.2019.01.067

Abstract:

Background: DNA damage repair (DDR) alterations are important events in cancer initiation, progression, and therapeutic resistance. However, the involvement of DDR alterations in glioma malignancy needs further investigation. This study aims to characterize the clinical and molecular features of gliomas with DDR alterations and elucidate the biological process of DDR alterations that regulate the cross talk between gliomas and the tumor microenvironment.

Keywords:
DNA damage repair, Microglia, Glioma microenvironment, p53, Midkine, Scopus, Web of Science

Тип: Article

DNA DAMAGE REPAIR ALTERATIONS MODULATE M2 POLARIZATION OF MICROGLIA TO REMODEL THE TUMOR MICROENVIRONMENT VIA THE P53-MEDIATED MDK EXPRESSION IN GLIOMA

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