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ГЕНЕТИЧЕСКИЕ МАРКЕРЫ ОСТЕОАРТРИТА У ЖЕНЩИН С НЕДИФФЕРЕНЦИРОВАННОЙ ДИСПЛАЗИЕЙ СОЕДИНИТЕЛЬНОЙ ТКАНИ

Хусаинова Р.И., Тюрин А.В., Шаповалова Д.А., Хуснутдинова Э.К.

Дата публикации: 2017

DOI: 10.1134/S1022795417060072

ключевые слова:
ВАК

Тип: Article



SEARCH FOR OSTEOARTHRITIS GENETIC MARKERS IN WOMEN WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

Khusainova, R.I., Tyurin, A.V., Shapovalova, D.A., Khusnutdinova, E.K.

Publication date: 2017

DOI: 10.1134/S1022795417060072

Abstract:

We conducted an association study of ten polymorphisms in six candidate genes of OA (rs1799750 (MMP1), rs35068180 (MMP3), rs2252070 (MMP13), rs63118460 and rs2276455 (COL2A1), rs143383 (GDF5), rs1544410, rs7975232, rs731236, and rs2228570 (VDR)) with the development of osteoarthritis (OA) in 333 women taking into account the localization of the pathological process, the age of disease manifestation, and ethnicity and investigated the presence of signs of undifferentiated connective tissue dysplasia (UCTD). On the basis of clinical and genetic data, we revealed statistically significant models to predict the development of osteoarthritis of various localizations (knee, hip, and generalized forms).

Keywords:
osteoarthritis, arthrosis, genetic predisposition, connective tissue dysplasia, candidate genes, Scopus, Web of Science

Тип: Article



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