Статья
SYNTHESIS AND ANTIULCER ACTIVITY OF 3-0-ACYLATED GLYCYRRHETIC ACID METHYLATES
2001
Typically possessing low toxicity and a broad spectrum of biological activity, plant triterpenoids are valuable raw materials for the creation of new drugs [1 – 4]. Of special interest in this respect are the major triterpenoids contained in the root extract obtained from plants of the common licorice (Glycyrrhiza glabra L.) and Ural licorice (Glycyrrhiza uralensis Fisher ) species. These substances are represented by 18 -glycyrrhetic acid (I) and its modified analogs, which serve as the base for effective antiinflammatory, antiallergic, and antiulcer preparations [2, 5 – 9]. The antiulcer drugs include the sodium salt of acid I (glycyrrhenate sodium) [2] and the disodium salt of acid I succinate (carbenoxolone, II)
Кондратенко, Р.М., Балтина, Л.А., Исмагилова, А.Ф., Васильева, Е.В., Насыров, Х.М., Толстиков, Г.А., , , , , . 2001;
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