SYNTHESIS AND NOOTROPIC ACTIVITY OF NEW 3-AMINO-12-N-METHYLCYTISINE DERIVATIVES

Макара, Н.С.; Вахитова, Ю.В.; Зарудий, Ф.С.; Tsypysheva, I.P.; Kovalskaya, A.V.; Lobov, A.N.; Petrova, P.R.; Farafontova, E.I.; Zainullina, L.F.; Makara N.S.; Vakhitova, Yu.V.; Zarudii, F.S.

SYNTHESIS AND NOOTROPIC ACTIVITY OF NEW 3-AMINO-12-N-METHYLCYTISINE DERIVATIVES

Tsypysheva, I.P., Kovalskaya, A.V., Lobov, A.N., Petrova, P.R., Farafontova, E.I., Zainullina, L.F., Makara N.S., Vakhitova, Yu.V., Zarudii, F.S.

Publication date: 2015

Abstract:

Reductive alkylation of 3-amino-12-N-methylcytisine by aromatic aldehydes synthesized a series of secondary amines. The nootropic activity of the synthesized compounds was studied in vivo (mnestic and antihypoxic properties) and in vitro (antiradical properties and ability to affect transcription factor HIF-1 DNA-binding activity). The cytotoxicity of the synthesized compounds was assessed. The lead compound was identified

Keywords:
(–)-cytisine, nootropic activity, mnestic effect, antihypoxic properties, antiradical properties, AOS, TF HIF-1

Тип: Article

DOI 10.1007/s10600-015-1446-x

SYNTHESIS AND NOOTROPIC ACTIVITY OF NEW 3-AMINO-12-N-METHYLCYTISINE DERIVATIVES

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